Introduction
Earlier I had described solid amoebic liver
abscess based on my experience at the autopsy and
isotope imaging. [1,2] At that time, some of my
collegues raised eyebrows at my labelling an abscess
as "solid". I describe below further five
cases.
Material
& Methods
During the last seven years from my clinic and
cases admitted to Jaslok Hospital, I collected five
cases of amoebic liver abscess who
- Had
positive serological tests (l.H.A. in titre
of > 1: 250)
- Had cold
areas on isotope liver scan
- Whose
sonography showed a sonodense lesion in the
liver (Fig. 1, Fig. 2). With 13
number wide needle, diagnostic tapping was
tried in these patients. Only in one patient
2 ml. of thick pus was aspirated. In the
rest, tapping was negative.
The above
patients were treated with injections of Emetine and
a course of Metronidazole or Tinadazole. All the five
patients recovered completely and the follow up
imaging done after four months by either isotope
liver scan or sonography showed a complete
disappearance of the lesion.
Discussion
CT Imaging of pancreas has shown that after an
attack of acute pancreatitis, modern imaging can
differentiate between the complications of an
abscess, pseudo-pancreatic cyst and phlegmon. The
last is a "solid" inflammatory mass. In our
country the other common solid inflammatory mass in
the liver is tuberculoma. At times this can mimic
solid amoebic liver abscess very much. Solid hydatid
cyst (without secondary infection) of the liver has
also been described recently. [3] Similarly modern
imaging has confirmed my impression that amoebic
abscess can be solid.
Discussion
Solid S.O.L. can occur in the liver in amoebic or
tuberculous infections (Fig. 3). Unfortunately,
serological tests for amoebiasis have not become
available all over our country. Also I.H.A. test done
commonly is very sensitive, but not specific. Not
only it could be falsely positive, even when
positive, at least one more test like C.I.E.A. test
or Fluorescence antibody test should also be done.
Similarly in our country, in adults, Mantoux test
does not help in diagnosis. So often we see 12-16 mm.
positive without any active kochs focus in the body.
A Therapeutic test for amoebiasis in this situation
may be worthwhile. But it must be kept in mind that
solid amoebic abscess is a rare type of amoebic
abscess. Also solid tuberculoma is a rare type of
hepatic tuberculosis where not only full antikochs
treatment will be required, but surgical enucleation
of this mass may be required, since in our
experience, this much mass, unlike in the case of
brain tuberculoma, would not dissolve with antikochs
drugs.
Therefore, patients having a solid S.O.L. in the
liver should be investigated thoroughly in big
medical centres. Serological tests for amoebiasis
must be done. Laparoscopy can also be done in such
patients and the mass can be biopsied. In other
cases, presence of small tubercles elsewhere in the
liver or specially on the peritoneum or the other
viscera would click the diagnosis as against an
amoebic pathology. Adhesions around the mass would
possibly differentiate from lymphoma or other
malignant deposits.
This patient's experience also shows that if the
patient does not respond within 2 to 3 months of
starting antikochs therapy, surgical treatment should
not be delayed in such type of liver tuberculosis.
Summary
A case of solid tuberculoma of the liver as a
case of S.O.L. has been presented. It has been
discussed that how closely, it can mimic solid
amoebic abscess. It has also been shown that such
patients may need surgical treatment, when at
laparotomy the whole mass can be enucleated.
Acknowledgement
I am grateful to Dr. N. H. Keswani, Medical
Director, Jaslok Hospital, & Research Centre,
Bombay for allowing me to publish this material
KAPOOR 0P :
Hepatic Tuberculosis. Bulletin of the Jaslok Hospital
& Research Centre 2: 32: 1976.
LELE RD,
KAPOOR 0P, KAKKAR VC, CHITALE, ARUN : Fever of
obscure origin Bulletin of the Jaslok Hospital &
Research Centre, 1: 18: 1976.
In fact this diagnosis is a very responsible one and
should not be made without a positive serological
test. Fortunately, these tests are now easily
available.
Earlier I had described eighteen cases of solid
amoebic liver abscess. [l] At the autopsy, these
lesions mimic deposits of lymphoma, malignancy or
tuberculomas (Fig. 3). In our country, since
tuberculosis of liver can also result in pyrexia,
hepatic discomfort and hepatic enlargement, if a
S.O.L. is seen on imaging, a tuberculoma can easily
be mistaken for a solid amoebic liver abscess.
Pai [2] had earlier confirmed my finding of a solid
amoebic liver abscess. I have now confirmed beyond
doubt that like a pancreatic phlegmon, amoebic
infection can be solid too. More the reason, that in
our country, we should increase availability of
serological tests for amoebiasis. With the result,
that in future, moment any solid S.O.L. is seen in
the liver, with a clinical picture and a positive
amoebic serological test, antiamoebic drugs should be
started.
Also I must add that in a number of patients of
amoebic liver abscess, "part" of the mass
seen on sonography is hyperechoic (solid) .
Summary
Five cases of solid amoebic liver abscess
confirmed by sonography are presented. It is stressed
that in our country, serological tests for amoebiasis
should be used freely, not to mistake other solid
lesions in the liver specially tuberculoma.
Acknowledgement
I am grateful to Dr. N. H. Keswani, Medical Director,
Jaslok Hospital & Research Centre, Bombay for
allowing me to publish this material.
References
- KAPOOR 0.
P.: A. L. A. S. S. Publishers, Bombay, 156:
1979.
- PAI R. R.
quoted by KAPOOR 0. P.: S. S. Publishers,
Bombay 157, 1979.
- EVANGELOS
E. D.: et al Varied sonographic patterns in
Echinococcus liver diseases. J. Clin
Ultrasound 13: 627, 1985.