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Abstracts
of Papers Presented at the 114th Research Meeting of The Medical
Research Centre of Bombay Hospital, Convenor Dr. HL Dhar.
Abstract of papers presented
at the 115th Research Meeting of The Medical Research Centre of
Bombay Hospital, Convenor Dr. HL Dhar.
Abstracts of papers presented at the 116th Research Meeting of
The Medical Research Centre of Bombay Hospital, Convenor Dr. HL
Dhar. |
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1. Newer modality in investigation
of glaucoma
Jayasree, RC Patel |
New investigative modalities in glaucoma is an insight
in to ill understood glaucoma. For years it went unnoticed
because of lack of investigative procedures, but the quest
for perfection led to many methods. This is a compilation
of the procedures, which would lead to early detection
of this end stage disease and help us in instituting the
therapy. |
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2. Cerebrospinal fluid rhinorrhoea
Anamika Rathod, Nishit Shah |
It is defined as the leakage of CSF from the nose due
to communication with the subarachnoid space. With the
alarming rise in road traffic accidents, the incidence
of CSF rhinorrhoea has greatly increased. Trauma comprises
80% of CSF leaks followed by iatrogenic leaks - 16% and
non-traumatic spontaneous leaks. The most common traumatic
site is fovea ethmoidalis, while most common site for
atraumatic fistula is the cribriform area. To diagnose
this condition we have to confirm the leak followed by
its localization. The management can be conservative or
surgical. The surgical approach is divided into intracranial,
extracranial and endoscopic. Of these the transnasal endoscopic
repair remains the treatment of choice in most of the
situations. Advantages (a) providing excellent field of
vision, allowing exact localization of leak,. (b) the
ability to precisely close the defect with minimal disruption
of normal anatomy, (c) accurate placement of graft material
over the defect and (d) reduced morbidity. We have above
50 patients. Who had undergone endoscopic CSF repair.
So with the advent of endoscopy CSF leak is no longer
a threat. |
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3. Endonasal transsphenoidal pituitary surgery
Navnit Mukul, Nishit Shah |
Advances in optics, miniaturization and endoscopic
instrumentation have revolutionized surgery in the past
decade. The endoscopic endonasal transsphenoidal approach
has become the preferred approach for pituitary adenoma
and other sellar lesions. Endoscopes of different angles
(0,30,45,70 degrees) provide direct visualization of the
surgical field with better illumination. Endoscopes provide
panoramic view of complex anatomy of the nose and paranasal
sinuses, sellar region and surrounding structures and
thus improves the extent of tumour resection and reduces
the risk of complications. This approach does not require
any external surgical incisions. Patient has less postoperative
complaints and thus less hospital stay. We at Bombay Hospital
have performed more than 200 endoscopic pituitary surgeries
and other sellar operations with encouraging results.
In our experience it proved to be a safer and better technique.
We would like to present our technique and results. |
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4. Importance of eustachian tube in humans
NK Apte, Navnit Mukul |
It is the most important part of middle ear cleft responsible
for development of air conduction for mobility of ear
ossicles for hearing in all terrestial animals. In man
it is important for development of speech. The purpose
of this paper is to highlight the interesting features
in the normal anatomy of eustachian tube, its development
and evolution in vertebrates and related pathologies.
In man normally it remains closed and opens only during
swallowing to establish equillibrium between the middle
ear and outside. Dysfunction of the eustachian tube is
seen in cases of suppurative otitismiddle ear and outside.
Dysfunction of the eustachian tube is seen in cases of
suppurative otitis media, congenital anomalies of the
head and neck and tumours in the nasopharynx. Moreover
we are able to understand better aetiopathogenesis of
adhesive otitis, masked mastoiditis, petrositis, and other
pathologies for better management. |
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5. Rush disease - management
Shreyas Palav, Karobi Lahiri |
| 15 patients of Rush Disease were seen in the last 3 years
of which 4 pairs of twins were examined and treated. The
examination, intervention, mode of treatment, extensiveness
of treatment, follow up, progression and Management of complications
will be discussed. |
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6. A case study of cryptophthalmos
Shreyas Palav, Karobi Lahiri |
| Cryptophthalmos : An unusual congenital anomaly of autosomal
recessive inheritance in which the globe and the deeper
ocular structures are covered by a fold of skin which extends
from brow to cheek. The eye consists of a mal or underdeveloped
sclera lined by neuroectoderm. Further classified as complete
or total, incomplete or partial, abortive. |
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| LET FOOD BE THY MEDICINE |
It was in 1931 that Lucy Wills described how yeast
extract could be effective in preventing tropical macrocytic
anaemia of late pregnancy. Folate was shown to be the
crucial factor. In the 1980s a series of studies showed
how periconceptional folate could prevent spina bifida.
Then in 1995 came a meta-analysis that established that
high homocysteine concentrations were a risk factor for
atherosclerosis. Dietary folate reduces homocysteine,
raising the possibility that a vitamin might prevent vascular
disease. Next, several nucleotide polymorphisms were found
to be related to folate, meaning that folate levels might
influence the chance of developing cancer.
Folate may thus be a leading contender for panacea of
the 21st century. Addition of folate to foods might reduce
birth defects, vascular disease, and heart disease - and
the Americans favour fortifying bread with folate. But
folate being involved in so many of life's fundamental
processes not only leads to its possibilities as a panacea
but also to the prospect that "messing around with
folate" could do extensive harm. The folate used
in food fortification is not a natural co-enzyme, and
nobody knows the long term effects of exposing whole populations
to the unnatural folate.
There is thus great potential for good, some possibility
of harm, and much uncertainty. The question of fortifying
foods inevitably becomes highly political, and the politics
of nutrition are just as complex as the science.
Richard Smith, BMJ, 2004; 328 : 180.
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