POST-THROMBOLYSIS
ROUTINE ANGIOPLASTY
Early post-thrombolysis routine angioplasty is discouraged
in patients with ST-segment elevated myocardial infarction
(STEMI) because of a high incidence of events. The GRACIA-1
trial was designed to reassess the benefits of this
approach in the era of stents and new antiplatelet agents.
Francisco Fernandez-Aviles and colleagues did a randomised
controlled trial in 500 patients with thrombolysed STEMI
who were randomly assigned to angiography and intervention,
or to an ischaemia-guided conservative approach. Early
post-thrombolysis catheterisation and intervention was
safe and reduced the combined rate of death, reinfarction,
and revascularisation at 1 year. In a comment paper,
Freek WA Verheugt suggests that an approach such as
lyse now, stent later might be more helpful in reducing
longterm mortality than an immediate approach.
BMJ,
2004: 1014, 1045.