Day by day, the population of our country is
increasing and the doctor-patient ratio is reducing. It is all
the more important that many patients having lifetime diseases
should be educated to look after themselves and to contact doctors
only when required. This holds true for hypertension, diabetes
mellitus and many other common diseases. With future generations
becoming smarter, more educated and computer savvy, the patient
should be guided by the family physicians about more and more
diseases. A very good example is a case of bronchial asthma
or epilepsy, where self education is essential. Remember that
the income of the family physician will not be affected as long
as they start charging consulting fees, whenever they examine
or advise a patient.
Similarly, hypothyroidism is a lifelong disease, usually caused
due to destruction of thyroid cells by:
1) auto antibodies and 2) in recent times, by the radioactive
iodine treatment, given to patients of Graves’ disease.
A few patients of hypothyroidism may be exception.
I am highlighting a few points, which can be enlarged upon
by the family physician. They are as follows:-
- When a hypothyroid pregnant woman gives birth to a child,
the diagnosis of cretinism should be established in the newborn
as early as possible and treatment started.
- In young children, if the physical and mental growth has
to be kept normal, thyroid therapy should be given in accurate
doses. Otherwise, the family physician will be blamed by the
parents later on.
- Just as a diabetic is taught to adjust the doses of his
medicine by the level of his blood sugar, a hypothyroid patient
should get his blood level of TSH and T4 tested every year
(may be every 6 months to maximum of 2 years) to make sure
that his requirements of thyroid replacement are adequately
adjusted.
- In a young, pregnant woman, often the dose of thyroid needs
to be increased to look after the growing foetus. This point
is to be stressed upon the family members.
- Iron capsules prescribed for common illness like anaemia
will interact with absorption of thyroxine.
- Hyperacidity has become more or less universal. Antacids
taken along with thyroxine, will interfere with its absorption.
- Many young women especially during pregnancy and post partum,
are prescribed calcium tablets. Calcium taken along with thyroxine,
can reduce its absorption.
- When a female patient attains menopause, often the requirement
of thyroid falls. In such a case, the dose should be adjusted
by testing the TSH and T4 every 6 months.
- Finally, during old age, patients of hypothyroidism are
more prone to ischaemic heart disease because of high lipids.
Vice versa, the incidence of hypothyroidism increases with
age. With the result, a family physician can expect 10% of
his elderly population to have hypothyroidism (picked up by
routine TSH.levels and not by a clinical picture). Thus, a
patient who presents with angina pectoris could have hypothyroidism.
Remember that these patients can be extremely sensitive to
a dose of thyroxine tablet. I have seen three deaths in private
practice, which occurred suddenly because of the above situation.
Thus there is no hurry to start treating hypothyroidism as
the patient can continue to live his life, though subnormally.
It is very important to evaluate these patients in detail.
Try to persuade such a patient for an interventional procedure
in addition to medical treatment for angina before wanting
to show off your skill by changing his appearance by giving
him thyroxine tablets. The tablets should be given in a very
small dose like 50 microgram, especially after angina pectoris
is controlled. A known patient of hypothyroidism, when diagnosed
as a case of angina pectoris should tell the cardiologist
that he has hypothyroidism. Thus angina pectoris associated
with hypothyroidism should always be handled as if you are
treating a case of unstable angina.
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NarrowED
retinal arterioles predict development of hypertension
People with narrowed retinal vessels are more likely
to develop hypertension. Following up 2451 people who
had normal blood pressure and had had the diameter of
retinal arterioles and venules measured at baseline,
Wong and colleagues found that, at 10 years, people
with the smallest vessel ratio had three times the risk
of developing hypertension than did those with the highest
ratio. Small vessel disease may be linked with the development
of hypertension, say the authors, and it may be a target
for antihypertensive treatment.
BMJ,
2004; 329 : 79.
Role of Orbital Radiotherapy in Thyroid Eye
Disease is Controversial
Reviewing recent developments in thyroid eye disease,
Cawood and colleagues say that numerous retrospective,
uncontrolled studies led to the use of radiotherapy,
but in recent prospective, placebo controlled trials
it led to little or no improvement. The authors identify
smoking as the most important risk factor for developing
thyroid eye disease and list the pitfalls in diagnosis,
which include uniocular presentation. They emphasise
the need for specialist management by a thyroidologist
and an ophthalmologist
BMJ, 2004; 329 : 385.
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