LOW-DOSE ASPIRIN AND CARDIOVASCULAR DISEASE IN WOMEN
In men low-dose aspirin prevents myocardial infarction but not stroke. In this large study of low-dose aspirin in healthy women, the opposite was found: there was no reduction in the risk of myocardial infarction, but the risk of stroke was significantly decreased owing to a reduction in the risk of ischaemic stroke with a small increase in the risk of haemorrhagic stroke. Thus, low-dose aspirin for cardiovascular prevention appears to have different effects in men and women.
N Engl J Med 2005; 352 : 1281. SCREENING FOR ABDOMINAL ANEURYSM SAVES LIVES
Mass screening of men aged 65 and over for abdominal aortic aneurysm reduces mortality. Lindholt and colleagues randomised 12639 Danish men to receive an invitation for screening with ultrasound or no invitation. More than three quarters of the group offered the investigation attended, and 4% of those screened had abdominal aortic aneurysms. Screening reduced the rate of emergency surgery, the number of deaths due to abdominal aortic aneurysm, and specific and all cause mortality. The number needed to screen to save one life was 352.
BMJ, 2005; 330 : 750. |