Introduction
Respiratory illnesses in workers of stone crushing industries is a significant problem all over the world. One million people are dying annually in the world. 1.7 million are affected in India alone. Billions of rupees are spent on their treatment annually.
We took this study because hundreds of stone crushers are spread around our city, Guntur, employing thousands of workers. They are frequently seen in our hospital in pulmonology unit. They are reportedly occupying around 60% of pulmonology ward beds. To get the actual picture we did this field study.
By our study, we established that a number of stone crushing workers are suffering from respiratory diseases than those of ornamental workers (non- exposed).
Material and Methods
Type of study : Cross-sectional.
Study design : Field based.
Period of study : From September 2004 to January 2005, a total of five months.
Sample Size : A set of 125 workers from two different occupations were studied regarding respiratory abnormalities. Out of the sample 50 are stone crushing workers (exposed) and 75 are ornamental industry workers (non-exposed).
Apparatus : Tailor tape – chest expansion, Wrights peak expiratory flow meter – P.E.F.R.
Method
Study population was selected on the following criteria :-
- The age group was between 35-50 years
- Minimum period of occupation in their respective field was 2 years
- Low socio economic status
- Body mass index of 23-26 are taken
- Only non-smokers are taken into consideration
- Same height and sex calculated for differences.
The age group was taken between 35-50 years because it is the ideal age where a person can be adequately exposed to a particular occupation, very young age produces symptoms lately after years of exposure; very old age group creates a variety of confounding factors because of their physiological changes.1
The minimum period of occupation in their respective fields was taken two years, so that study groups are adequately exposed to their working environment.1 Care is taken not to include workers who first worked in stone crushing industry and changed their occupation to ornamental industry.
Low socio economic status is taken to normalize their education and other protective measures, and also low socio economic status is an independent risk factor for chronic respiratory illnesses.2
As PEFR changes with height and sex, they are adjusted for such differences. PEFR (L/min) = [Height (cm) - 80] x 5.13,14
Quantitative measurements like PEFR and chest expansions are noted using Wright’s peak expiratory flow meter and measuring tape respectively.
All the readings were taken in evening after their work is completed.
PEFR of 400 to 500 litres/minute was taken as normal for males and 300-400 litres/ minute was taken as normal for females.3
The chest expansion of 5 cm is taken as normal workers with body mass index of 23-26 are only taken because chest expansion and PEFR differ with obesity and leanness.4
Results
Persons who are non-exposed are more likely to have normal chest expansion and normal PEFR than exposed persons are. That is chest expansion and PEFR are more likely to be negative indicators of respiratory disease. The percentages of normal indicators for Workers who are not exposed to dust are high; than the percentages of abnormal indicators for exposed workers.
Discussion
Measurement of respiratory disease by peak expiratory flow meter and chest expansion are very good instrument in clinical practice.12 This is a simple method of measuring airway disease and it will detect moderate or severe disease. The simplicity of the method is its main advantage. It is measured using a standard Wright Peak Flow Meter or mini Wright Meter and Measuring tape.
From the tables it can be noted that, Normal chest expansion is 37% in exposed compared to 55% in non-exposed, that is non-exposed persons are more likely to have normal chest expansion than exposed persons (Table 2, Fig. 2).
Like wise, Normal PEFR is more likely to be present in non-exposed (53%) than inexposed (35%) (Table 1, Fig. 1).1,5
To conclude, persons who are non-exposed are more likely to have normal chest expansion and normal PEFR than exposed persons.8-11
References
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3. Pelosi P, Ravagnan I, Giurati G, et al. Positive end-expiratory pressure improves respiratory function in obese but not in normal subjects during anaesthesia and paralysis. Anaesthesiology 1999; 91 (5) : 1221-31. PMID: 10551570 [PubMed - indexed for MEDLINE].
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Fig.2 |
Respiratory impairments due to dust exposure: a comparative study among workers exposed to silica, asbestos and coalmine dust. Am J Ind Med 1997; 31 (5) : 495-502. PMID: 9099350 [PubMed - indexed for MEDLINE].
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12. Jones KP, Mullee MA. Measuring peak expiratory flow in general practice: comparison of mini Wright peak flow meter and turbine spirometer.
13. Normal values are related to the patient’s height. http://www.med.monash.edu.au/paediatrics/resources/pefr.html.
14. Rajendra Prasad, Verma SK, Agrawal GG, Neeraj Mathur. Prediction Model for Peak Expiratory Flow in North-Indian Population. Indian J Chest Dis Allied Sci 2006; 48 : 103-6.
MISOPROSTOL FOR PREGNANCY TERMINATION
`Administration interval can be chosen between 3 h and 12 h when misoprostol is given vaginally. If administration is sublingual, the intervals between misoprostol doses need to be short, but side-effects are then increased'
The medical abortion regimen of mifepristone followed by a suitable prostaglandin analogue, most commonly misoprostol, is available in over 30 countries for termination of early pregnancy. However, the most effective administration routes and doses of misoprostol used alone for early abortion have not been defined. Helena von Hertzen and colleagues did a randomised controlled equivalence trial to assess the effects of the interval between multiple doses of misoprostol and the route of administration to terminate pregnancy. When vaginal administration is used, the intervals between misoprostol doses can range from 3 h to 12 h without significantly affecting efficacy. However, if misoprostol is given sublingually, 3-h intervals, between multiple doses are more effective than 12-h intervals, but at the cost of higher rates of side-effects. In a Comment, Beverly Winikoff and Anne Rachel Davis discuss the importance of this study and consider all aspects of abortion for women.
Lancet Oncol, 2007; 8 : 1904, 1938.
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